Site-Directed Mutagenesis

Precise point, deletion, and insertion mutations with trade-secret methods

≤ 10 Business Days Delivery

Precision Mutations for Structure-Function Studies

Our Site-Directed Mutagenesis service delivers precise genetic modifications with industry-leading speed and reliability. Using our proprietary low-fail workflow, we create point mutations, deletions, and insertions in your plasmids with high fidelity.

We've optimized our mutagenesis protocols to minimize failure rates while maintaining rapid turnaround times. Whether you need a single amino acid substitution or multiple mutations for SAR studies, our trade-secret methods ensure consistent success even with challenging sequences.

Perfect for protein engineering, structure-activity relationship (SAR) studies, functional screens, and any research requiring precise genetic modifications. Our pricing scales efficiently with variant count, making large mutagenesis campaigns cost-effective.

Quick Facts

Mutation Types
Point, Deletion, Insertion
Delivery Time
≤ 10 days
Pricing Model
Scales with variants
Success Rate
Low-fail workflow

Service Specifications

🧬 Core Specifications

  • Point mutations (single or multiple)
  • Deletion mutations (any size)
  • Insertion mutations (up to 40 bp standard)
  • Trade-secret method for faster, low-fail rate mutagenesis
  • Price scales with number of variants per order
  • 100% sequence verification included

Popular Add-Ons

  • Large insertions/deletions >40 bp (treated as RGS+SC)
  • Multiple mutation sites in single construct
  • Combinatorial mutagenesis libraries
  • Saturation mutagenesis at specific positions
  • Codon-optimized replacements
  • Silent mutations for restriction site introduction

Typical Applications

SAR studies and functional screens

Structure-Activity Studies

Systematic mutation of key residues to understand protein function, binding affinity, and catalytic activity for drug discovery applications.

Epitope Mapping

Identify critical antibody binding sites through alanine scanning or targeted mutations to optimize therapeutic antibody development.

Enzyme Engineering

Improve enzyme stability, specificity, or activity through targeted mutations at active sites or structural regions.

Regulatory Element Analysis

Modify promoters, enhancers, or UTRs to understand and optimize gene expression levels for research or therapeutic applications.

Ready to Start Your Mutagenesis Project?

Get precise mutations delivered in 10 days or less